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miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer
Joint Authors
Sun, Jue
Xu, Yuejuan
Xu, Jianhua
Li, Qi
Zhang, Qiang
Guo, Yuewu
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Gastric cancer (GC) is an important malignant disease around the world.
Abnormalities of microRNAs (miRNAs) have been implicated in carcinogenesis of various cancers.
In the present study, we examined miR-21 expression in human gastric cancer with lymph node metastasis and attempted to uncover its relationship with clinicopathologic data, especially with lymph node metastasis.
Materials and Methods.
The expression levels of miR-21 in the tumor specimens of GC patients were quantified by RT-PCR.
The correlation between miR-21 level and multiple clinicopathological factors was then examined by Mann-Whitney test, Kaplan-Meier survival analysis, and operating characteristic (ROC) analysis.
Results.
The expression level of miR-21 was higher in GC patients with lymph node metastasis than in those without lymph node metastasis (P<0.05).
Expression level of miR-21 was significantly correlated with histologic type, T stage, lymph node metastasis and pTNM stage.
The overall survival rates in GC patients with low upregulated miR-21 expression were significantly higher than those with high upregulated miR-21 (P<0.05).
Conclusion.
A close association is implicated between the elevated miR-21and lymph node metastasis, which could potentially be exploited as a practical biomarker for lymph node metastasis in patients with GC.
American Psychological Association (APA)
Xu, Yuejuan& Sun, Jue& Xu, Jianhua& Li, Qi& Guo, Yuewu& Zhang, Qiang. 2012. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487389
Modern Language Association (MLA)
Xu, Yuejuan…[et al.]. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-487389
American Medical Association (AMA)
Xu, Yuejuan& Sun, Jue& Xu, Jianhua& Li, Qi& Guo, Yuewu& Zhang, Qiang. miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-487389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487389