FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey
المؤلفون المشاركون
Isi, Hilmi
Izci Ay, Ozlem
Erdal, M. Emin
Balkan, Mahmut
Akkoc, Hasan
Gedik, Abdullah
Budak, Turgay
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The influence of FSH receptor (FSHR) variants on male infertility is not completely understood.
The present investigation is the first screening study for SNP at nucleotide position −29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.
The SNPs in codon 680 and at position −29 of the FSHR gene were analyzed by PCR-RFLP technique in 240 men with proven fathers, and 270 infertile men (150 nonobstructive azoospermic and 120 severe oligozoospermic).
The separate analysis for SNP at nucleotide position −29 did not show any difference in genotypic frequencies and serum FSH levels.
The genotype distribution of SNP at position 680 was different but does not influence serum FSH levels.
Together the two SNPs form four discrete haplotypes (A-Thr-Asn, G-Thr-Asn, A-Ala-Ser, and G-Ala-Ser) occurring in 10 combinations.
A statistically significant difference in the allelic distribution of G-Asn/G-Ser and G-Ser/G-Ser genotype between proven fathers and infertile men but there were not any statistically significant difference in the overall frequency of the four FSHR haplotypes.
We conclude that the FSHR haplotype does not associate with different serum FSH levels but it is differently distributed in proven fathers and infertile men.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balkan, Mahmut& Gedik, Abdullah& Akkoc, Hasan& Izci Ay, Ozlem& Erdal, M. Emin& Isi, Hilmi…[et al.]. 2010. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-487400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balkan, Mahmut…[et al.]. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-487400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balkan, Mahmut& Gedik, Abdullah& Akkoc, Hasan& Izci Ay, Ozlem& Erdal, M. Emin& Isi, Hilmi…[et al.]. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-487400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر