FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey
Joint Authors
Isi, Hilmi
Izci Ay, Ozlem
Erdal, M. Emin
Balkan, Mahmut
Akkoc, Hasan
Gedik, Abdullah
Budak, Turgay
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The influence of FSH receptor (FSHR) variants on male infertility is not completely understood.
The present investigation is the first screening study for SNP at nucleotide position −29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey.
The SNPs in codon 680 and at position −29 of the FSHR gene were analyzed by PCR-RFLP technique in 240 men with proven fathers, and 270 infertile men (150 nonobstructive azoospermic and 120 severe oligozoospermic).
The separate analysis for SNP at nucleotide position −29 did not show any difference in genotypic frequencies and serum FSH levels.
The genotype distribution of SNP at position 680 was different but does not influence serum FSH levels.
Together the two SNPs form four discrete haplotypes (A-Thr-Asn, G-Thr-Asn, A-Ala-Ser, and G-Ala-Ser) occurring in 10 combinations.
A statistically significant difference in the allelic distribution of G-Asn/G-Ser and G-Ser/G-Ser genotype between proven fathers and infertile men but there were not any statistically significant difference in the overall frequency of the four FSHR haplotypes.
We conclude that the FSHR haplotype does not associate with different serum FSH levels but it is differently distributed in proven fathers and infertile men.
American Psychological Association (APA)
Balkan, Mahmut& Gedik, Abdullah& Akkoc, Hasan& Izci Ay, Ozlem& Erdal, M. Emin& Isi, Hilmi…[et al.]. 2010. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-487400
Modern Language Association (MLA)
Balkan, Mahmut…[et al.]. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-487400
American Medical Association (AMA)
Balkan, Mahmut& Gedik, Abdullah& Akkoc, Hasan& Izci Ay, Ozlem& Erdal, M. Emin& Isi, Hilmi…[et al.]. FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-487400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487400