Unique Case Reports Associated with Ovarian Failure : Necessity of Two Intact X Chromosomes
المؤلفون المشاركون
Rao Kandukuri, Lakshmi
Swapna, Mangalipally
Saranaya, Govindaraghavan
Himaja, Kattera
Deenadayal, Mamata
Gupta, Nalini
Turlapati, Raseswari
Padmalatha, Venkata
Nallari, Pratibha
Singh, Lalji
Deb, Prasun
Chakraborthy, Baidyanath
Vidyadhari, Metuku
Kanakavalli, Murthy
Kumar Sethi, Bipin
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Premature ovarian failure is defined as the loss of functional follicles below the age of 40 years and the incidence of this abnormality is 0.1% among the 30–40 years age group.
Unexplained POF is clinically recognized as amenorrhoea (>6 months) with low level of oestrogen and raised level of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH > 20 IU/l) occurring before the age of 40.
It has been studied earlier that chromosomal defects can impair ovarian development and its function.
Since there is paucity of data on chromosomal defects in Indian women, an attempt is made to carry out cytogenetic evaluation in patients with ovarian failure.
Cytogenetic analysis of women with ovarian defects revealed the chromosome abnormalities to be associated with 14% of the cases analyzed.
Interestingly, majority of the abnormalities involved the X-chromosome and we report two unique abnormalities, (46,XXdel(Xq21-22) and q28) and (mos,45XO/46,X+ringX) involving X chromosome in association with ovarian failure.
This study revealed novel X chromosome abnormalities associated with ovarian defects and these observations would be helpful in genetic counseling and apart from, infertility clinics using the information to decide suitable strategies to help such patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rao Kandukuri, Lakshmi& Padmalatha, Venkata& Kanakavalli, Murthy& Turlapati, Raseswari& Swapna, Mangalipally& Vidyadhari, Metuku…[et al.]. 2012. Unique Case Reports Associated with Ovarian Failure : Necessity of Two Intact X Chromosomes. Case Reports in Genetics،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rao Kandukuri, Lakshmi…[et al.]. Unique Case Reports Associated with Ovarian Failure : Necessity of Two Intact X Chromosomes. Case Reports in Genetics No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rao Kandukuri, Lakshmi& Padmalatha, Venkata& Kanakavalli, Murthy& Turlapati, Raseswari& Swapna, Mangalipally& Vidyadhari, Metuku…[et al.]. Unique Case Reports Associated with Ovarian Failure : Necessity of Two Intact X Chromosomes. Case Reports in Genetics. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر