Reversible Dissociation and Ligand-Glutathione Exchange Reaction in Binuclear Cationic Tetranitrosyl Iron Complex with Penicillamine
المؤلفون المشاركون
Aldoshin, Sergey
Lyssenko, Konstantin
Kabachkov, Evgeniy
Psikha, Boris
Shkondina, Natal’ja
Syrtsova, Lidia
Sanina, Natalia
Pokidova, Olesia
Kotelnikov, Alexander
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This paper describes a comparative study of the decomposition of two nitrosyl iron complexes (NICs) with penicillamine thiolic ligands [Fe2(SC5H11NO2)2(NO)4]SO4·5H2O (I) and glutathione- (GSH-) ligands [Fe2(SC10H17N3O6)2(NO)4]SO4·2H2O (II), which spontaneously evolve to NO in aqueous medium.
NO formation was measured by a sensor electrode and by spectrophotometric methods by measuring the formation of a hemoglobin- (Hb-) NO complex.
The NO evolution reaction rate from (I) k1 = (4.6 ± 0.1)·10−3 s−1 and the elimination rate constant of the penicillamine ligand k2 = (1.8 ± 0.2)·10−3 s−1 at 25°C in 0.05 M phosphate buffer, pH 7.0, was calculated using kinetic modeling based on the experimental data.
Both reactions are reversible.
Spectrophotometry and mass-spectrometry methods have firmly shown that the penicillamine ligand is exchanged for GS− during decomposition of 1.5·10−4 M (I) in the presence of 10−3 M GSH, with 76% yield in 24 h.
As has been established, such behaviour is caused by the resistance of (II) to decomposition due to the higher affinity of iron to GSH in the complex.
The discovered reaction may impede S-glutathionylation of the essential enzyme systems in the presence of (I) and is important for metabolism of NIC, connected with its antitumor activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Syrtsova, Lidia& Sanina, Natalia& Lyssenko, Konstantin& Kabachkov, Evgeniy& Psikha, Boris& Shkondina, Natal’ja…[et al.]. 2014. Reversible Dissociation and Ligand-Glutathione Exchange Reaction in Binuclear Cationic Tetranitrosyl Iron Complex with Penicillamine. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Syrtsova, Lidia…[et al.]. Reversible Dissociation and Ligand-Glutathione Exchange Reaction in Binuclear Cationic Tetranitrosyl Iron Complex with Penicillamine. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-487511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Syrtsova, Lidia& Sanina, Natalia& Lyssenko, Konstantin& Kabachkov, Evgeniy& Psikha, Boris& Shkondina, Natal’ja…[et al.]. Reversible Dissociation and Ligand-Glutathione Exchange Reaction in Binuclear Cationic Tetranitrosyl Iron Complex with Penicillamine. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر