Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function
المؤلفون المشاركون
Oliveira, José Carlos
Santos, Josefina
Dias, Leonídio
Lobato, Luísa
Castro Henriques, António
Fonseca, Isabel
Cruz, Madalena
Almeida, Manuela
Mendonça, Denisa
Guedes, Anabela Malho
Martins, La Salete
Pedroso, Sofia
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx).
We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year.
Urine samples were collected on post-KTx days 0, 1, 2, 4, and 7.
Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used.
At all-time points, mean uNGAL levels were significantly higher in patients developing DGF (n=18).
Shortly after KTx (3–6 h), uNGAL values were higher in DGF recipients (on average +242 ng/mL, considering mean dialysis time of 4.1 years) and rose further in following days, contrasting with prompt function recipients.
Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95).
Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine.
Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fonseca, Isabel& Oliveira, José Carlos& Almeida, Manuela& Cruz, Madalena& Guedes, Anabela Malho& Martins, La Salete…[et al.]. 2013. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fonseca, Isabel…[et al.]. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-488189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fonseca, Isabel& Oliveira, José Carlos& Almeida, Manuela& Cruz, Madalena& Guedes, Anabela Malho& Martins, La Salete…[et al.]. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر