Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function
Joint Authors
Oliveira, José Carlos
Santos, Josefina
Dias, Leonídio
Lobato, Luísa
Castro Henriques, António
Fonseca, Isabel
Cruz, Madalena
Almeida, Manuela
Mendonça, Denisa
Guedes, Anabela Malho
Martins, La Salete
Pedroso, Sofia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx).
We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year.
Urine samples were collected on post-KTx days 0, 1, 2, 4, and 7.
Linear mixed and multivariable regression models, receiver-operating characteristic (ROC), and areas under ROC curves were used.
At all-time points, mean uNGAL levels were significantly higher in patients developing DGF (n=18).
Shortly after KTx (3–6 h), uNGAL values were higher in DGF recipients (on average +242 ng/mL, considering mean dialysis time of 4.1 years) and rose further in following days, contrasting with prompt function recipients.
Day-1 uNGAL levels accurately predicted DGF (AUC-ROC = 0.93), with a performance higher than serum creatinine (AUC-ROC = 0.76), and similar to cystatin C (AUC-ROC = 0.95).
Multivariable analyses revealed that uNGAL levels at days 4 and 7 were strongly associated with one-year serum creatinine.
Urinary NGAL is an early marker of graft injury and is independently associated with dialysis requirement within one week after KTx and one-year graft function.
American Psychological Association (APA)
Fonseca, Isabel& Oliveira, José Carlos& Almeida, Manuela& Cruz, Madalena& Guedes, Anabela Malho& Martins, La Salete…[et al.]. 2013. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488189
Modern Language Association (MLA)
Fonseca, Isabel…[et al.]. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-488189
American Medical Association (AMA)
Fonseca, Isabel& Oliveira, José Carlos& Almeida, Manuela& Cruz, Madalena& Guedes, Anabela Malho& Martins, La Salete…[et al.]. Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488189