Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
المؤلفون المشاركون
Terracina, Krista P.
Matsuda, Yasunobu
Kobayashi, Takashi
Soma, Daiki
Wakai, Toshifumi
Hirose, Yuki
Nagahashi, Masayuki
Takabe, Kazuaki
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival, migration, the recruitment of immune cells, angiogenesis, and lymphangiogenesis, all of which are involved in cancer progression.
S1P is generated inside cancer cells by sphingosine kinases then exported outside of the cell into the tumor microenvironment where it binds to any of five G protein coupled receptors and proceeds to regulate a variety of functions.
We have recently reported on the mechanisms underlying the “inside-out” signaling of S1P, its export through the plasma membrane, and its interaction with cell surface receptors.
Membrane lipids, including S1P, do not spontaneously exchange through lipid bilayers since the polar head groups do not readily go through the hydrophobic interior of the plasma membrane.
Instead, specific transporter proteins exist on the membrane to exchange these lipids.
This review summarizes what is known regarding S1P transport through the cell membrane via ATP-binding cassette transporters and the spinster 2 transporter and discusses the roles for these transporters in cancer and in the tumor microenvironment.
Based on our research and the emerging understanding of the role of S1P signaling in cancer and in the tumor microenvironment, S1P transporters and S1P signaling hold promise as new therapeutic targets for cancer drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nagahashi, Masayuki& Takabe, Kazuaki& Terracina, Krista P.& Soma, Daiki& Hirose, Yuki& Kobayashi, Takashi…[et al.]. 2014. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nagahashi, Masayuki…[et al.]. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-488345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nagahashi, Masayuki& Takabe, Kazuaki& Terracina, Krista P.& Soma, Daiki& Hirose, Yuki& Kobayashi, Takashi…[et al.]. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر