Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
Joint Authors
Terracina, Krista P.
Matsuda, Yasunobu
Kobayashi, Takashi
Soma, Daiki
Wakai, Toshifumi
Hirose, Yuki
Nagahashi, Masayuki
Takabe, Kazuaki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival, migration, the recruitment of immune cells, angiogenesis, and lymphangiogenesis, all of which are involved in cancer progression.
S1P is generated inside cancer cells by sphingosine kinases then exported outside of the cell into the tumor microenvironment where it binds to any of five G protein coupled receptors and proceeds to regulate a variety of functions.
We have recently reported on the mechanisms underlying the “inside-out” signaling of S1P, its export through the plasma membrane, and its interaction with cell surface receptors.
Membrane lipids, including S1P, do not spontaneously exchange through lipid bilayers since the polar head groups do not readily go through the hydrophobic interior of the plasma membrane.
Instead, specific transporter proteins exist on the membrane to exchange these lipids.
This review summarizes what is known regarding S1P transport through the cell membrane via ATP-binding cassette transporters and the spinster 2 transporter and discusses the roles for these transporters in cancer and in the tumor microenvironment.
Based on our research and the emerging understanding of the role of S1P signaling in cancer and in the tumor microenvironment, S1P transporters and S1P signaling hold promise as new therapeutic targets for cancer drug development.
American Psychological Association (APA)
Nagahashi, Masayuki& Takabe, Kazuaki& Terracina, Krista P.& Soma, Daiki& Hirose, Yuki& Kobayashi, Takashi…[et al.]. 2014. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488345
Modern Language Association (MLA)
Nagahashi, Masayuki…[et al.]. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-488345
American Medical Association (AMA)
Nagahashi, Masayuki& Takabe, Kazuaki& Terracina, Krista P.& Soma, Daiki& Hirose, Yuki& Kobayashi, Takashi…[et al.]. Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488345