Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy
المؤلفون المشاركون
Laino, Luigi
Suetti, Silvia
Sperduti, Isabella
المصدر
Dermatology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis.
Actually, the first-line treatment consists of local steroid as clobetasol propionate (CP).
Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast.
Objective.
To evaluate the efficacy of intradermal administration of PDRN in male patients suffering from genital lichen sclerosus in addition to topical 0.05% CP, as compared to administering 0.05% CP without PDRN injection.
Patients/Methods.
A group of male patients (n = 28; aged 25 to 65) suffering from LS were observed during topical therapy or subdermal in addition to topical therapy.
Disease activity at baseline was evaluated on Investigator’s Global Assessment (IGA) and the Dermatology Life Quality Index (DLQI).
We used polydeoxyribonucleotide in a commercial preparation for human use and a topical CP emulsion.
Results.
After therapy, in all group A patients there has been a regression of most of clinical pathological signs, while there has been a moderate improvement in all group B patients.
Conclusions.
On site intradermal administration of PDRN, associated with CP 0.05% cream, seemed to be associated with a clinical improvement of lichen sclerosus better than CP used in single therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laino, Luigi& Suetti, Silvia& Sperduti, Isabella. 2013. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laino, Luigi…[et al.]. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-488593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laino, Luigi& Suetti, Silvia& Sperduti, Isabella. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر