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Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy
Joint Authors
Laino, Luigi
Suetti, Silvia
Sperduti, Isabella
Source
Dermatology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Lichen sclerosus (LS) is an autoimmune inflammatory skin disease that leads to tissue sclerosis.
Actually, the first-line treatment consists of local steroid as clobetasol propionate (CP).
Polydeoxyribonucleotide (PDRN) has demonstrated anti-inflammatory effects through the reduction of cytokine production and growth stimulation of fibroblast.
Objective.
To evaluate the efficacy of intradermal administration of PDRN in male patients suffering from genital lichen sclerosus in addition to topical 0.05% CP, as compared to administering 0.05% CP without PDRN injection.
Patients/Methods.
A group of male patients (n = 28; aged 25 to 65) suffering from LS were observed during topical therapy or subdermal in addition to topical therapy.
Disease activity at baseline was evaluated on Investigator’s Global Assessment (IGA) and the Dermatology Life Quality Index (DLQI).
We used polydeoxyribonucleotide in a commercial preparation for human use and a topical CP emulsion.
Results.
After therapy, in all group A patients there has been a regression of most of clinical pathological signs, while there has been a moderate improvement in all group B patients.
Conclusions.
On site intradermal administration of PDRN, associated with CP 0.05% cream, seemed to be associated with a clinical improvement of lichen sclerosus better than CP used in single therapy.
American Psychological Association (APA)
Laino, Luigi& Suetti, Silvia& Sperduti, Isabella. 2013. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488593
Modern Language Association (MLA)
Laino, Luigi…[et al.]. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-488593
American Medical Association (AMA)
Laino, Luigi& Suetti, Silvia& Sperduti, Isabella. Polydeoxyribonucleotide Dermal Infiltration in Male Genital Lichen Sclerosus : Adjuvant Effects during Topical Therapy. Dermatology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488593