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Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer
المؤلفون المشاركون
Sandin, Fredrik
Åström, Lennart
Isacsson, Ulf
Johansson, Silvia
Turesson, Ingela
Montelius, Anders
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Proton boost of 20 Gy in daily 5 Gy fractions followed by external beam radiotherapy (EBRT) of 50 Gy in daily 2 Gy fractions were given to 278 patients with prostate cancer with T1b to T4N0M0 disease.
Fifty-three percent of the patients received neoadjuvant androgen deprivation therapy (N-ADT).
The medium followup was 57 months.
The 5-year PSA progression-free survival was 100%, 95%, and 74% for low-, intermediate-, and high-risk patients, respectively.
The toxicity evaluation was supported by a patient-reported questionnaire before every consultant visit.
Cumulative probability and actuarial prevalence of genitourinary (GU) and gastrointestinal (GI) toxicities are presented according to the RTOG classification.
N-ADT did not influence curability.
Mild pretreatment GU-symptoms were found to be a strong predictive factor for GU-toxicity attributable to treatment.
The actuarial prevalence declined over 3 to 5 years for both GU and GI toxicities, indicating slow resolution of epithelial damage to the genitourinary and gastrointestinal tract.
Bladder toxicities rather than gastrointestinal toxicities seem to be dose limiting.
More than 5-year followup is necessary to reveal any sign of true progressive late side effects of the given treatment.
Hypofractionated proton-boost combined with EBRT is associated with excellent curability of localized PC and acceptable frequencies of treatment toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Johansson, Silvia& Åström, Lennart& Sandin, Fredrik& Isacsson, Ulf& Montelius, Anders& Turesson, Ingela. 2012. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-488669
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Johansson, Silvia…[et al.]. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-488669
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Johansson, Silvia& Åström, Lennart& Sandin, Fredrik& Isacsson, Ulf& Montelius, Anders& Turesson, Ingela. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-488669
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488669
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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