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Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer
Joint Authors
Sandin, Fredrik
Åström, Lennart
Isacsson, Ulf
Johansson, Silvia
Turesson, Ingela
Montelius, Anders
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Proton boost of 20 Gy in daily 5 Gy fractions followed by external beam radiotherapy (EBRT) of 50 Gy in daily 2 Gy fractions were given to 278 patients with prostate cancer with T1b to T4N0M0 disease.
Fifty-three percent of the patients received neoadjuvant androgen deprivation therapy (N-ADT).
The medium followup was 57 months.
The 5-year PSA progression-free survival was 100%, 95%, and 74% for low-, intermediate-, and high-risk patients, respectively.
The toxicity evaluation was supported by a patient-reported questionnaire before every consultant visit.
Cumulative probability and actuarial prevalence of genitourinary (GU) and gastrointestinal (GI) toxicities are presented according to the RTOG classification.
N-ADT did not influence curability.
Mild pretreatment GU-symptoms were found to be a strong predictive factor for GU-toxicity attributable to treatment.
The actuarial prevalence declined over 3 to 5 years for both GU and GI toxicities, indicating slow resolution of epithelial damage to the genitourinary and gastrointestinal tract.
Bladder toxicities rather than gastrointestinal toxicities seem to be dose limiting.
More than 5-year followup is necessary to reveal any sign of true progressive late side effects of the given treatment.
Hypofractionated proton-boost combined with EBRT is associated with excellent curability of localized PC and acceptable frequencies of treatment toxicity.
American Psychological Association (APA)
Johansson, Silvia& Åström, Lennart& Sandin, Fredrik& Isacsson, Ulf& Montelius, Anders& Turesson, Ingela. 2012. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-488669
Modern Language Association (MLA)
Johansson, Silvia…[et al.]. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-488669
American Medical Association (AMA)
Johansson, Silvia& Åström, Lennart& Sandin, Fredrik& Isacsson, Ulf& Montelius, Anders& Turesson, Ingela. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-488669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488669