The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2

الملخص EN

Background.

We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression.

Methods and Results.

40 elective CABG patients were allocated into two groups.

The adenosine group (n=20) received 250 μg/kg adenosine into the aortic root followed by blood potassium cardioplegia.

The control group received potassium cardioplegia in blood.

Bcl-2 and bax were measured.

Bax was reduced in the postoperative biopsies (1.38 versus 0.47, P=.002) in the control group.

Bcl-2 showed a reducing tendency (0.14 versus 0.085, P=.07).

After the adenosine treatment, the expression of both bax (0.52 versus 0.59, P=.4) and bcl-2 (0.104 versus 0.107, P=.4) remained unaltered after the operation.

Conclusion.

Open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2.

Fast Adenosine induction abolished changes in their expression.