The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
Joint Authors
Porkkala, Helena
Saraste, Antti
Rinne, Timo
Laurikka, Jari
Latva-Hirvelä, Juha
Nuutila, Kristiina
Saukko, Pekka
Shalaby, Ahmed
Tarkka, Matti
Järvinen, Otso
Source
Cardiology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression.
Methods and Results.
40 elective CABG patients were allocated into two groups.
The adenosine group (n=20) received 250 μg/kg adenosine into the aortic root followed by blood potassium cardioplegia.
The control group received potassium cardioplegia in blood.
Bcl-2 and bax were measured.
Bax was reduced in the postoperative biopsies (1.38 versus 0.47, P=.002) in the control group.
Bcl-2 showed a reducing tendency (0.14 versus 0.085, P=.07).
After the adenosine treatment, the expression of both bax (0.52 versus 0.59, P=.4) and bcl-2 (0.104 versus 0.107, P=.4) remained unaltered after the operation.
Conclusion.
Open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2.
Fast Adenosine induction abolished changes in their expression.
American Psychological Association (APA)
Shalaby, Ahmed& Rinne, Timo& Järvinen, Otso& Latva-Hirvelä, Juha& Nuutila, Kristiina& Saraste, Antti…[et al.]. 2009. The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2. Cardiology Research and Practice،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-488953
Modern Language Association (MLA)
Shalaby, Ahmed…[et al.]. The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2. Cardiology Research and Practice No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-488953
American Medical Association (AMA)
Shalaby, Ahmed& Rinne, Timo& Järvinen, Otso& Latva-Hirvelä, Juha& Nuutila, Kristiina& Saraste, Antti…[et al.]. The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2. Cardiology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-488953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488953
