Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy
المؤلفون المشاركون
Goyal, Sharad
Haffty, Bruce G.
Schiff, Devora
Wu, Hao
Taunk, Neil K.
Pirlamarla, Aneesh
Kim, Sinae
Ferro, Adam
المصدر
International Journal of Breast Cancer
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy.
Methods and Materials.
Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabetic patients and diabetic patients using an alternative diabetes medication.
Primary endpoints included the presence of a treatment break and development of dry or moist desquamation.
Results.
There was a statistically significant increase in treatment breaks for diabetic patients receiving concurrent metformin when compared to the nondiabetic patients (P value = 0.02) and a trend toward significance when compared to diabetic patients receiving an alternate diabetes medication (P value = 0.08).
Multiple logistic regression analysis demonstrated concurrent metformin use as being associated with a trend toward the predictive value of determining the incidence of developing desquamation in diabetic patients receiving radiation therapy compared to diabetic patients receiving an alternate diabetes medication (P value = 0.06).
Conclusions.
Diabetic patients treated with concurrent metformin and radiation therapy developed increased acute locoregional toxicity in comparison with diabetic patients receiving an alternate diabetes medication and nondiabetic patients.
Further clinical investigation should be conducted to determine the therapeutic ratio of metformin in combination with radiation therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferro, Adam& Goyal, Sharad& Kim, Sinae& Wu, Hao& Taunk, Neil K.& Schiff, Devora…[et al.]. 2013. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferro, Adam…[et al.]. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-489049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferro, Adam& Goyal, Sharad& Kim, Sinae& Wu, Hao& Taunk, Neil K.& Schiff, Devora…[et al.]. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر