Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy
Joint Authors
Goyal, Sharad
Haffty, Bruce G.
Schiff, Devora
Wu, Hao
Taunk, Neil K.
Pirlamarla, Aneesh
Kim, Sinae
Ferro, Adam
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy.
Methods and Materials.
Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabetic patients and diabetic patients using an alternative diabetes medication.
Primary endpoints included the presence of a treatment break and development of dry or moist desquamation.
Results.
There was a statistically significant increase in treatment breaks for diabetic patients receiving concurrent metformin when compared to the nondiabetic patients (P value = 0.02) and a trend toward significance when compared to diabetic patients receiving an alternate diabetes medication (P value = 0.08).
Multiple logistic regression analysis demonstrated concurrent metformin use as being associated with a trend toward the predictive value of determining the incidence of developing desquamation in diabetic patients receiving radiation therapy compared to diabetic patients receiving an alternate diabetes medication (P value = 0.06).
Conclusions.
Diabetic patients treated with concurrent metformin and radiation therapy developed increased acute locoregional toxicity in comparison with diabetic patients receiving an alternate diabetes medication and nondiabetic patients.
Further clinical investigation should be conducted to determine the therapeutic ratio of metformin in combination with radiation therapy.
American Psychological Association (APA)
Ferro, Adam& Goyal, Sharad& Kim, Sinae& Wu, Hao& Taunk, Neil K.& Schiff, Devora…[et al.]. 2013. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489049
Modern Language Association (MLA)
Ferro, Adam…[et al.]. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-489049
American Medical Association (AMA)
Ferro, Adam& Goyal, Sharad& Kim, Sinae& Wu, Hao& Taunk, Neil K.& Schiff, Devora…[et al.]. Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-489049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489049