Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
المؤلفون المشاركون
Tanaka, Tomofumi
Ohno, Yohei
Murata, Mitsushige
Hattori, Fumiyuki
Fukuda, Keiichi
Kaneda, Ruri
Seki, Tomohisa
Egashira, Toru
Tohyama, Shugo
Hashimoto, Hisayuki
Kageyama, Toshimi
Yae, Kojiro
Kimura, Kensuke
Kunitomi, Akira
Saito, Yuki
Shimoji, Kenichiro
Onizuka, Takeshi
Yuasa, Shinsuke
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells.
This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells.
Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use.
Therefore, the aims of the present study were to assess (1) the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2) the properties of the iPS cell-derived cardiomyocytes.
We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes.
Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohno, Yohei& Yuasa, Shinsuke& Egashira, Toru& Seki, Tomohisa& Hashimoto, Hisayuki& Tohyama, Shugo…[et al.]. 2013. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohno, Yohei…[et al.]. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-489051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohno, Yohei& Yuasa, Shinsuke& Egashira, Toru& Seki, Tomohisa& Hashimoto, Hisayuki& Tohyama, Shugo…[et al.]. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر