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Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
Joint Authors
Tanaka, Tomofumi
Ohno, Yohei
Murata, Mitsushige
Hattori, Fumiyuki
Fukuda, Keiichi
Kaneda, Ruri
Seki, Tomohisa
Egashira, Toru
Tohyama, Shugo
Hashimoto, Hisayuki
Kageyama, Toshimi
Yae, Kojiro
Kimura, Kensuke
Kunitomi, Akira
Saito, Yuki
Shimoji, Kenichiro
Onizuka, Takeshi
Yuasa, Shinsuke
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells.
This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells.
Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use.
Therefore, the aims of the present study were to assess (1) the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2) the properties of the iPS cell-derived cardiomyocytes.
We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes.
Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.
American Psychological Association (APA)
Ohno, Yohei& Yuasa, Shinsuke& Egashira, Toru& Seki, Tomohisa& Hashimoto, Hisayuki& Tohyama, Shugo…[et al.]. 2013. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489051
Modern Language Association (MLA)
Ohno, Yohei…[et al.]. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-489051
American Medical Association (AMA)
Ohno, Yohei& Yuasa, Shinsuke& Egashira, Toru& Seki, Tomohisa& Hashimoto, Hisayuki& Tohyama, Shugo…[et al.]. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489051