Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation
المؤلفون المشاركون
de Oliveira, Pollyanna Francielli
Moreno, Gabriela de Padua
Rodrigues, Marina Rezende
Berretta, Andresa Aparecida
Barizon, Edna Aparecida
Costa-Machado, Ana Rita de Mello
Rocha, Bruno Alves
Martins, Sabrina de Paula Lima
Bueno, Paula Carolina Pires
Rodrigues, Andresa Piacezzi Nascimento
Ferreira, Nathália Ursoli
Campos, Jacqueline Costa Lima
Acésio, Nathália de Oliveira
Vaz, Mirela Mara de Oliveira Lima Leite
Tavares, Denise Crispim
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Since the beginning of propolis research, several groups have studied its antibacterial, antifungal, and antiviral properties.
However, most of these studies have only employed propolis ethanolic extract (PEE) leading to little knowledge about the biological activities of propolis water extract (PWE).
Based on this, in a previous study, we demonstrated the anti-inflammatory and immunomodulatory activities of PWE.
In order to better understand the equilibrium between effectiveness and toxicity, which is essential for a new medicine, the characteristics of PWE were analyzed.
We developed and validated an RP-HPLC method to chemically characterize PWE and PEE and evaluated the in vitro antioxidant/antimicrobial activity for both extracts and the safety of PWE via determining genotoxic potential using in vitro and in vivo mammalian micronucleus assays.
We have concluded that the proposed analytical methodology was reliable, and both extracts showed similar chemical composition.
The extracts presented antioxidant and antimicrobial effects, while PWE demonstrated higher antioxidant activity and more efficacious for the most of the microorganisms tested than PEE.
Finally, PWE was shown to be safe using micronucleus assays.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha, Bruno Alves& Bueno, Paula Carolina Pires& Vaz, Mirela Mara de Oliveira Lima Leite& Rodrigues, Andresa Piacezzi Nascimento& Ferreira, Nathália Ursoli& Moreno, Gabriela de Padua…[et al.]. 2013. Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489110
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha, Bruno Alves…[et al.]. Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-489110
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha, Bruno Alves& Bueno, Paula Carolina Pires& Vaz, Mirela Mara de Oliveira Lima Leite& Rodrigues, Andresa Piacezzi Nascimento& Ferreira, Nathália Ursoli& Moreno, Gabriela de Padua…[et al.]. Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-489110
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489110
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر