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Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications
المؤلفون المشاركون
Tielliu, Ignace F.
de Hart, Jurgen
van Oeveren, Wim
المصدر
International Journal of Biomaterials
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Three different models, a modified Chandler loop, roller pump, and a new ball valve model (Hemobile), were compared with regard to intrinsic damage of blood components and activation of platelets.
The Hemobile was used for testing of polymer tubes.
High flow was not possible with the Chandler loop.
The roller pump and the Hemobile could be adjusted to high flow, but he pump induced hemolysis.
Platelet numbers were reduced in the roller pump and Chandler loop (P<0.05), but remained high in the Hemobile.
Platelet aggregation was reduced in all models.
The Hemobile was applied for testing vascular graft materials, and allowed different circuits circulated simultaneously at 37°C.
ePTFE, Dyneema Purity UHMWPE fiber and PET fiber based tubes, all showed hemolysis below 0.2% and reduced platelet count and function.
Binding of fibrin and platelets was higer on PET, inflammatory markers were lowest on Dyneema Purity UHMWPE.
We concluded that the Hemobile minimally affects blood and could be adjusted to high blood flows, simulating arterial shear stress.
The Hemobile was used to measure hemocompatibility of graft material and showed Dyneema Purity UHMWPE fiber in many ways more hemocompatible than ePTFE and PET.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
van Oeveren, Wim& Tielliu, Ignace F.& de Hart, Jurgen. 2012. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
van Oeveren, Wim…[et al.]. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-489370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
van Oeveren, Wim& Tielliu, Ignace F.& de Hart, Jurgen. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489370
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