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Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications
Joint Authors
Tielliu, Ignace F.
de Hart, Jurgen
van Oeveren, Wim
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Three different models, a modified Chandler loop, roller pump, and a new ball valve model (Hemobile), were compared with regard to intrinsic damage of blood components and activation of platelets.
The Hemobile was used for testing of polymer tubes.
High flow was not possible with the Chandler loop.
The roller pump and the Hemobile could be adjusted to high flow, but he pump induced hemolysis.
Platelet numbers were reduced in the roller pump and Chandler loop (P<0.05), but remained high in the Hemobile.
Platelet aggregation was reduced in all models.
The Hemobile was applied for testing vascular graft materials, and allowed different circuits circulated simultaneously at 37°C.
ePTFE, Dyneema Purity UHMWPE fiber and PET fiber based tubes, all showed hemolysis below 0.2% and reduced platelet count and function.
Binding of fibrin and platelets was higer on PET, inflammatory markers were lowest on Dyneema Purity UHMWPE.
We concluded that the Hemobile minimally affects blood and could be adjusted to high blood flows, simulating arterial shear stress.
The Hemobile was used to measure hemocompatibility of graft material and showed Dyneema Purity UHMWPE fiber in many ways more hemocompatible than ePTFE and PET.
American Psychological Association (APA)
van Oeveren, Wim& Tielliu, Ignace F.& de Hart, Jurgen. 2012. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489370
Modern Language Association (MLA)
van Oeveren, Wim…[et al.]. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-489370
American Medical Association (AMA)
van Oeveren, Wim& Tielliu, Ignace F.& de Hart, Jurgen. Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions : Application in Thrombogenicity Testing of Different Materials for Vascular Applications. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-489370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489370