Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels

المؤلفون المشاركون

Wang, Chen
Xie, Li
Li, Bin
Poyton, Robert O.
Li, Tianlin
Lu, Shu-Ping
Castello, Pablo R.
Easlon, Erin
Tsang, Felicia
Kato, Michiko
Skinner, Craig J.
Lin, Su-Ju

المصدر

Journal of Aging Research

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-03-31

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

الملخص EN

Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear.

Recent studies suggest that CR-induced mitochondrial activity is associated with nitric oxide (NO) production.

To understand the role of mitochondria in CR, we identify and study Saccharomyces cerevisiae mutants with increased NO levels as potential CR mimics.

Analysis of the top 17 mutants demonstrates a correlation between increased NO, mitochondrial respiration, and longevity.

Interestingly, treating yeast with NO donors such as GSNO (S-nitrosoglutathione) is sufficient to partially mimic CR to extend lifespan.

CR-increased NO is largely dependent on mitochondrial electron transport and cytochrome c oxidase (COX).

Although COX normally produces NO under hypoxic conditions, CR-treated yeast cells are able to produce NO under normoxic conditions.

Our results suggest that CR may derepress some hypoxic genes for mitochondrial proteins that function to promote the production of NO and the extension of lifespan.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Bin& Skinner, Craig J.& Castello, Pablo R.& Kato, Michiko& Easlon, Erin& Xie, Li…[et al.]. 2011. Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-489374

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Bin…[et al.]. Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels. Journal of Aging Research No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-489374

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Bin& Skinner, Craig J.& Castello, Pablo R.& Kato, Michiko& Easlon, Erin& Xie, Li…[et al.]. Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-489374

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-489374