Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Johnson, David W.
Klein, Kerenaftali
Rossi, Megan
Campbell, Katrina L.
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-19
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Objective.
This paper assessed the effectiveness of pre-, pro-, and synbiotics on reducing two protein-bound uremic toxins, p-cresyl sulphate (PCS) and indoxyl sulphate (IS).
Methods.
English language studies reporting serum, urinary, or fecal PCS and/or IS (or their precursors) following pre-, pro-, or synbiotic interventions (>1 day) in human adults were included.
Population estimates of differences in the outcomes between the pre- and the postintervention were estimated for subgroups of studies using four meta-analyses.
Quality was determined using the GRADE approach.
Results.
19 studies met the inclusion criteria, 14 in healthy adults and five in haemodialysis patients.
Eight studies investigated prebiotics, six probiotics, one synbiotics, one both pre- and probiotics, and three studies trialled all three interventions.
The quality of the studies ranged from moderate to very low.
12 studies were included in the meta-analyses with all four meta-analyses reporting statistically significant reductions in IS and PCS with pre- and probiotic therapy.
Conclusion.
There is a limited but supportive evidence for the effectiveness of pre- and probiotics on reducing PCS and IS in the chronic kidney disease population.
Further studies are needed to provide more definitive findings before routine clinical use can be recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rossi, Megan& Klein, Kerenaftali& Johnson, David W.& Campbell, Katrina L.. 2012. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-489416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rossi, Megan…[et al.]. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-489416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rossi, Megan& Klein, Kerenaftali& Johnson, David W.& Campbell, Katrina L.. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-489416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر