Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis
Joint Authors
Johnson, David W.
Klein, Kerenaftali
Rossi, Megan
Campbell, Katrina L.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Objective.
This paper assessed the effectiveness of pre-, pro-, and synbiotics on reducing two protein-bound uremic toxins, p-cresyl sulphate (PCS) and indoxyl sulphate (IS).
Methods.
English language studies reporting serum, urinary, or fecal PCS and/or IS (or their precursors) following pre-, pro-, or synbiotic interventions (>1 day) in human adults were included.
Population estimates of differences in the outcomes between the pre- and the postintervention were estimated for subgroups of studies using four meta-analyses.
Quality was determined using the GRADE approach.
Results.
19 studies met the inclusion criteria, 14 in healthy adults and five in haemodialysis patients.
Eight studies investigated prebiotics, six probiotics, one synbiotics, one both pre- and probiotics, and three studies trialled all three interventions.
The quality of the studies ranged from moderate to very low.
12 studies were included in the meta-analyses with all four meta-analyses reporting statistically significant reductions in IS and PCS with pre- and probiotic therapy.
Conclusion.
There is a limited but supportive evidence for the effectiveness of pre- and probiotics on reducing PCS and IS in the chronic kidney disease population.
Further studies are needed to provide more definitive findings before routine clinical use can be recommended.
American Psychological Association (APA)
Rossi, Megan& Klein, Kerenaftali& Johnson, David W.& Campbell, Katrina L.. 2012. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-489416
Modern Language Association (MLA)
Rossi, Megan…[et al.]. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-489416
American Medical Association (AMA)
Rossi, Megan& Klein, Kerenaftali& Johnson, David W.& Campbell, Katrina L.. Pre-, Pro-, and Synbiotics : Do They Have a Role in Reducing Uremic Toxins? A Systematic Review and Meta-Analysis. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-489416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489416