DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil
المؤلفون المشاركون
Amaral, Cátia Lira do
Curi, Rui
Milagro, Fermín I.
Martínez, J. Alfredo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Dietary factors modulate gene expression and are able to alter epigenetic signatures in peripheral blood mononuclear cells (PBMC).
However, there are limited studies about the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on the epigenetic mechanisms that regulate gene expression.
This research investigates the effects of n-3-rich fish oil supplementation on DNA methylation profile of several genes whose expression has been reported to be downregulated by n-3 PUFA in PBMC: CD36, FFAR3, CD14, PDK4, and FADS1.
Young overweight women were supplemented with fish oil or control in a randomized 8-week intervention trial following a balanced diet with 30% energy restriction.
Fatty acid receptor CD36 decreased DNA methylation at CpG +477 due to energy restriction.
Hypocaloric diet-induced weight loss also reduced the methylation percentages of CpG sites located in CD14, PDK4, and FADS1.
The methylation patterns of these genes were only slightly affected by the fish oil supplementation, being the most relevant to the attenuation of the weight loss-induced decrease in CD36 methylation after adjusting by baseline body weight.
These results suggest that the n-3 PUFA-induced changes in the expression of these genes in PBMC are not mediated by DNA methylation, although other epigenetic mechanisms cannot be discarded.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amaral, Cátia Lira do& Milagro, Fermín I.& Curi, Rui& Martínez, J. Alfredo. 2014. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489553
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amaral, Cátia Lira do…[et al.]. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-489553
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amaral, Cátia Lira do& Milagro, Fermín I.& Curi, Rui& Martínez, J. Alfredo. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489553
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489553
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر