DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil
Joint Authors
Amaral, Cátia Lira do
Curi, Rui
Milagro, Fermín I.
Martínez, J. Alfredo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dietary factors modulate gene expression and are able to alter epigenetic signatures in peripheral blood mononuclear cells (PBMC).
However, there are limited studies about the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on the epigenetic mechanisms that regulate gene expression.
This research investigates the effects of n-3-rich fish oil supplementation on DNA methylation profile of several genes whose expression has been reported to be downregulated by n-3 PUFA in PBMC: CD36, FFAR3, CD14, PDK4, and FADS1.
Young overweight women were supplemented with fish oil or control in a randomized 8-week intervention trial following a balanced diet with 30% energy restriction.
Fatty acid receptor CD36 decreased DNA methylation at CpG +477 due to energy restriction.
Hypocaloric diet-induced weight loss also reduced the methylation percentages of CpG sites located in CD14, PDK4, and FADS1.
The methylation patterns of these genes were only slightly affected by the fish oil supplementation, being the most relevant to the attenuation of the weight loss-induced decrease in CD36 methylation after adjusting by baseline body weight.
These results suggest that the n-3 PUFA-induced changes in the expression of these genes in PBMC are not mediated by DNA methylation, although other epigenetic mechanisms cannot be discarded.
American Psychological Association (APA)
Amaral, Cátia Lira do& Milagro, Fermín I.& Curi, Rui& Martínez, J. Alfredo. 2014. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489553
Modern Language Association (MLA)
Amaral, Cátia Lira do…[et al.]. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-489553
American Medical Association (AMA)
Amaral, Cátia Lira do& Milagro, Fermín I.& Curi, Rui& Martínez, J. Alfredo. DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-489553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489553