Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency
المؤلفون المشاركون
Bordo, Gal
Carroll, Ty B.
Thomas, James P.
Kim, Julie
Kelly, Daniel F.
Findling, James W.
Duong, Huy T.
Wong, Yee Lan
Takasumi, Yuki
Cornell, Robert Frank
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
Adrenocorticotropin- (ACTH-) secreting pituitary carcinomas are rare and require multimodality treatment.
The aim of this study was to report the response to various therapies and discuss the potential development of secondary adrenal insufficiency with cytotoxic chemotherapy.
Methods.
This report describes a man with a large silent corticotroph adenoma progressing to endogenous hypercortisolism and metastatic ACTH-secreting pituitary carcinoma over a period of 14 years.
Results.
Seven years after initial presentation, progressive tumor enlargement associated with the development of hypercortisolism mandated multiple pituitary tumor debulking procedures and radiotherapy.
Testing of the Ki-67 proliferation index was markedly high and he developed a hepatic metastasis.
Combination therapy with cisplatin and etoposide resulted in a substantial reduction in tumor size, near-complete regression of his liver metastasis, and dramatic decrease in ACTH secretion.
This unexpectedly resulted in symptomatic secondary adrenal insufficiency.
Conclusions.
This is the first reported case of secondary adrenal insufficiency after use of cytotoxic chemotherapy for metastatic ACTH-secreting pituitary carcinoma.
High proliferative indices may be predictive of dramatic responses to chemotherapy.
Given the potential for such responses, the development of secondary adrenal insufficiency may occur and patients should be monitored accordingly.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cornell, Robert Frank& Kelly, Daniel F.& Bordo, Gal& Carroll, Ty B.& Duong, Huy T.& Kim, Julie…[et al.]. 2013. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489577
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cornell, Robert Frank…[et al.]. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-489577
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cornell, Robert Frank& Kelly, Daniel F.& Bordo, Gal& Carroll, Ty B.& Duong, Huy T.& Kim, Julie…[et al.]. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489577
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489577
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر