Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency
Joint Authors
Bordo, Gal
Carroll, Ty B.
Thomas, James P.
Kim, Julie
Kelly, Daniel F.
Findling, James W.
Duong, Huy T.
Wong, Yee Lan
Takasumi, Yuki
Cornell, Robert Frank
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Adrenocorticotropin- (ACTH-) secreting pituitary carcinomas are rare and require multimodality treatment.
The aim of this study was to report the response to various therapies and discuss the potential development of secondary adrenal insufficiency with cytotoxic chemotherapy.
Methods.
This report describes a man with a large silent corticotroph adenoma progressing to endogenous hypercortisolism and metastatic ACTH-secreting pituitary carcinoma over a period of 14 years.
Results.
Seven years after initial presentation, progressive tumor enlargement associated with the development of hypercortisolism mandated multiple pituitary tumor debulking procedures and radiotherapy.
Testing of the Ki-67 proliferation index was markedly high and he developed a hepatic metastasis.
Combination therapy with cisplatin and etoposide resulted in a substantial reduction in tumor size, near-complete regression of his liver metastasis, and dramatic decrease in ACTH secretion.
This unexpectedly resulted in symptomatic secondary adrenal insufficiency.
Conclusions.
This is the first reported case of secondary adrenal insufficiency after use of cytotoxic chemotherapy for metastatic ACTH-secreting pituitary carcinoma.
High proliferative indices may be predictive of dramatic responses to chemotherapy.
Given the potential for such responses, the development of secondary adrenal insufficiency may occur and patients should be monitored accordingly.
American Psychological Association (APA)
Cornell, Robert Frank& Kelly, Daniel F.& Bordo, Gal& Carroll, Ty B.& Duong, Huy T.& Kim, Julie…[et al.]. 2013. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489577
Modern Language Association (MLA)
Cornell, Robert Frank…[et al.]. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-489577
American Medical Association (AMA)
Cornell, Robert Frank& Kelly, Daniel F.& Bordo, Gal& Carroll, Ty B.& Duong, Huy T.& Kim, Julie…[et al.]. Chemotherapy-Induced Regression of an Adrenocorticotropin-Secreting Pituitary Carcinoma Accompanied by Secondary Adrenal Insufficiency. Case Reports in Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-489577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489577