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Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
المؤلفون المشاركون
Kim, Donghee
Chae, Sungwook
Seo, Eunhui
Jun, Hee-Sook
Lee, Mi-Young
Oh, Yoon Sin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The accumulation of oxidative damage and mitochondrial dysfunction is an important factor that contributes to aging.
The Psoralea corylifolia seeds (PCS), commonly known as “Boh-Gol-Zhee” in Korea, have been used traditionally as a medicinal remedy.
We investigated whether an extract of PCS has protective effects on oxidative stress and mitochondrial function in hepatocytes.
The PCS extract showed an antisenescence effect on human diploid fibroblasts as evidenced by a decreased expression of p16INK4a mRNA and senescence-associated β-galactosidase staining.
PCS extract treatment reduced H2O2-induced reactive oxygen species (ROS) production in HepG2 cells, inhibited ROS production in hepatocytes of aged mice, and increased superoxide dismutase activity.
In H2O2-treated HepG2 cells, PCS extract treatment recovered ATP production.
PCS extract treatment recovered the oxygen consumption rate and inhibited reduction of mitochondrial membrane potential induced by oxidative stress, suggesting improvement of mitochondrial function.
In addition, PCS extract treatment recovered peroxisome proliferator-activated receptor γ coactivator 1α and carnitine palmitoyltransferase 1 mRNA and protein expression, and inhibited mitochondrial genome damage.
Treatment with the major component of PCS extract, bakuchiol, also recovered mitochondrial dysfunction.
On the basis of these results, we conclude that PCS extract inhibits ROS production and mitochondrial dysfunction induced by oxidative stress in hepatocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seo, Eunhui& Oh, Yoon Sin& Kim, Donghee& Lee, Mi-Young& Chae, Sungwook& Jun, Hee-Sook. 2013. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seo, Eunhui…[et al.]. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seo, Eunhui& Oh, Yoon Sin& Kim, Donghee& Lee, Mi-Young& Chae, Sungwook& Jun, Hee-Sook. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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