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Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
Joint Authors
Kim, Donghee
Chae, Sungwook
Seo, Eunhui
Jun, Hee-Sook
Lee, Mi-Young
Oh, Yoon Sin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The accumulation of oxidative damage and mitochondrial dysfunction is an important factor that contributes to aging.
The Psoralea corylifolia seeds (PCS), commonly known as “Boh-Gol-Zhee” in Korea, have been used traditionally as a medicinal remedy.
We investigated whether an extract of PCS has protective effects on oxidative stress and mitochondrial function in hepatocytes.
The PCS extract showed an antisenescence effect on human diploid fibroblasts as evidenced by a decreased expression of p16INK4a mRNA and senescence-associated β-galactosidase staining.
PCS extract treatment reduced H2O2-induced reactive oxygen species (ROS) production in HepG2 cells, inhibited ROS production in hepatocytes of aged mice, and increased superoxide dismutase activity.
In H2O2-treated HepG2 cells, PCS extract treatment recovered ATP production.
PCS extract treatment recovered the oxygen consumption rate and inhibited reduction of mitochondrial membrane potential induced by oxidative stress, suggesting improvement of mitochondrial function.
In addition, PCS extract treatment recovered peroxisome proliferator-activated receptor γ coactivator 1α and carnitine palmitoyltransferase 1 mRNA and protein expression, and inhibited mitochondrial genome damage.
Treatment with the major component of PCS extract, bakuchiol, also recovered mitochondrial dysfunction.
On the basis of these results, we conclude that PCS extract inhibits ROS production and mitochondrial dysfunction induced by oxidative stress in hepatocytes.
American Psychological Association (APA)
Seo, Eunhui& Oh, Yoon Sin& Kim, Donghee& Lee, Mi-Young& Chae, Sungwook& Jun, Hee-Sook. 2013. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489724
Modern Language Association (MLA)
Seo, Eunhui…[et al.]. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-489724
American Medical Association (AMA)
Seo, Eunhui& Oh, Yoon Sin& Kim, Donghee& Lee, Mi-Young& Chae, Sungwook& Jun, Hee-Sook. Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-489724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489724