Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates
المؤلفون المشاركون
Pakshir, Keyvan
Rezaei, Zahra
Khabnadideh, Soghra
Mohtashami, Nadia
Zomorodian, Kamiar
Faghih Mirzaei, Ehsan
Nadali, Setareh
المصدر
International Journal of Medicinal Chemistry
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities.
These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds.
In order to synthesize α-aminophosphonates, catalytic effect of CuCl2 was compared with FeCl3.
Also all designed structures as well as griseofulvin were docked into the active site of microtubule (1JFF), using Autodock program.
The results showed that the reactions were carried out in the presence of CuCl2 in lower yields, and also the time of reaction was longer in comparison with FeCl3.
The chemical structures of the new compounds were confirmed by spectral analyses.
The compounds were investigated for antifungal activity against several fungi in comparison with griseofulvin.
An indole-derived bis(α-aminophosphonates) with the best negative ΔG in docking study showed maximum antifungal activity against Microsporum canis, and other investigated compounds did not have a good antifungal activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rezaei, Zahra& Khabnadideh, Soghra& Zomorodian, Kamiar& Pakshir, Keyvan& Nadali, Setareh& Mohtashami, Nadia…[et al.]. 2011. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489732
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rezaei, Zahra…[et al.]. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-489732
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rezaei, Zahra& Khabnadideh, Soghra& Zomorodian, Kamiar& Pakshir, Keyvan& Nadali, Setareh& Mohtashami, Nadia…[et al.]. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489732
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489732
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر