Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates
Joint Authors
Pakshir, Keyvan
Rezaei, Zahra
Khabnadideh, Soghra
Mohtashami, Nadia
Zomorodian, Kamiar
Faghih Mirzaei, Ehsan
Nadali, Setareh
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities.
These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds.
In order to synthesize α-aminophosphonates, catalytic effect of CuCl2 was compared with FeCl3.
Also all designed structures as well as griseofulvin were docked into the active site of microtubule (1JFF), using Autodock program.
The results showed that the reactions were carried out in the presence of CuCl2 in lower yields, and also the time of reaction was longer in comparison with FeCl3.
The chemical structures of the new compounds were confirmed by spectral analyses.
The compounds were investigated for antifungal activity against several fungi in comparison with griseofulvin.
An indole-derived bis(α-aminophosphonates) with the best negative ΔG in docking study showed maximum antifungal activity against Microsporum canis, and other investigated compounds did not have a good antifungal activity.
American Psychological Association (APA)
Rezaei, Zahra& Khabnadideh, Soghra& Zomorodian, Kamiar& Pakshir, Keyvan& Nadali, Setareh& Mohtashami, Nadia…[et al.]. 2011. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489732
Modern Language Association (MLA)
Rezaei, Zahra…[et al.]. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-489732
American Medical Association (AMA)
Rezaei, Zahra& Khabnadideh, Soghra& Zomorodian, Kamiar& Pakshir, Keyvan& Nadali, Setareh& Mohtashami, Nadia…[et al.]. Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-489732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489732