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Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress
المؤلفون المشاركون
Lau, Chi Wai
Lin, Zhixiu
Zhang, Huina
Huang, Yu
Leung, Sin Bond
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases through increased oxidative stress.
Salidroside is an active ingredient of the root of Rhodiola rosea with documented antioxidative, antihypoxia and neuroprotective properties.
However, the vascular benefits of salidroside against endothelial dysfunction have yet to be explored.
The present study, therefore, aimed to investigate the protective effect of salidroside on homocysteine-induced endothelial dysfunction.
Functional studies on the rat aortas were performed to delineate the vascular effect of salidroside.
DHE imaging was used to evaluate the reactive oxygen species (ROS) level in aortic wall and endothelial cells.
Western blotting was performed to assess the protein expression associated with oxidative stress and nitric oxide (NO) bioavailability.
Exposure to homocysteine attenuated endothelium-dependent relaxations in rat aortas while salidroside pretreatment rescued it.
Salidroside inhibited homocystein-induced elevation in the NOX2 expression and ROS overproduction in both aortas and cultured endothelial cells and increased phosphorylation of eNOS which was diminished by homocysteine.
The present study shows that salidroside is effective in preserving the NO bioavailability and thus protects against homocysteine-induced impairment of endothelium-dependent relaxations, largely through inhibiting the NOX2 expression and ROS production.
Our results indicate a therapeutic potential of salidroside in the management of oxidative-stress-associated cardiovascular dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leung, Sin Bond& Zhang, Huina& Lau, Chi Wai& Huang, Yu& Lin, Zhixiu. 2013. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489901
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leung, Sin Bond…[et al.]. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-489901
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leung, Sin Bond& Zhang, Huina& Lau, Chi Wai& Huang, Yu& Lin, Zhixiu. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489901
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489901
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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