Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress
Joint Authors
Lau, Chi Wai
Lin, Zhixiu
Zhang, Huina
Huang, Yu
Leung, Sin Bond
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases through increased oxidative stress.
Salidroside is an active ingredient of the root of Rhodiola rosea with documented antioxidative, antihypoxia and neuroprotective properties.
However, the vascular benefits of salidroside against endothelial dysfunction have yet to be explored.
The present study, therefore, aimed to investigate the protective effect of salidroside on homocysteine-induced endothelial dysfunction.
Functional studies on the rat aortas were performed to delineate the vascular effect of salidroside.
DHE imaging was used to evaluate the reactive oxygen species (ROS) level in aortic wall and endothelial cells.
Western blotting was performed to assess the protein expression associated with oxidative stress and nitric oxide (NO) bioavailability.
Exposure to homocysteine attenuated endothelium-dependent relaxations in rat aortas while salidroside pretreatment rescued it.
Salidroside inhibited homocystein-induced elevation in the NOX2 expression and ROS overproduction in both aortas and cultured endothelial cells and increased phosphorylation of eNOS which was diminished by homocysteine.
The present study shows that salidroside is effective in preserving the NO bioavailability and thus protects against homocysteine-induced impairment of endothelium-dependent relaxations, largely through inhibiting the NOX2 expression and ROS production.
Our results indicate a therapeutic potential of salidroside in the management of oxidative-stress-associated cardiovascular dysfunction.
American Psychological Association (APA)
Leung, Sin Bond& Zhang, Huina& Lau, Chi Wai& Huang, Yu& Lin, Zhixiu. 2013. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489901
Modern Language Association (MLA)
Leung, Sin Bond…[et al.]. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-489901
American Medical Association (AMA)
Leung, Sin Bond& Zhang, Huina& Lau, Chi Wai& Huang, Yu& Lin, Zhixiu. Salidroside Improves Homocysteine-Induced Endothelial Dysfunction by Reducing Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489901