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Inhibition of Nuclear Nox4 Activity by Plumbagin : Effect on Proliferative Capacity in Human Amniotic Stem Cells
المؤلفون المشاركون
Bertoni, Laura
Zavatti, Manuela
Beretti, Francesca
Resca, Elisa
Maraldi, Tullia
La Sala, Giovanni B.
Guida, Marianna
De Pol, Anto
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Human amniotic fluid stem cells (AFSC) with multilineage differentiation potential are novel source for cell therapy.
However, in vitro expansion leads to senescence affecting differentiation and proliferative capacities.
Reactive oxygen species (ROS) have been involved in the regulation of stem cell pluripotency, proliferation, and differentiation.
Redox-regulated signal transduction is coordinated by spatially controlled production of ROS within subcellular compartments.
NAD(P)H oxidase family, in particular Nox4, has been known to produce ROS in the nucleus; however, the mechanisms and the meaning of this function remain largely unknown.
In the present study, we show that Nox4 nuclear expression (nNox4) increases during culture passages up to cell cycle arrest and the serum starvation causes the same effect.
With the decrease of Nox4 activity, obtained with plumbagin, a decline of nuclear ROS production and of DNA damage occurs.
Moreover, plumbagin exposure reduces the binding between nNox4 and nucleoskeleton components, as Matrin 3.
The same effect was observed also for the binding with phospho-ERK, although nuclear ERK and P-ERK are unchanged.
Taken together, we suggest that nNox4 regulation may have important pathophysiologic effects in stem cell proliferation through modulation of nuclear signaling and DNA damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guida, Marianna& Maraldi, Tullia& Resca, Elisa& Beretti, Francesca& Zavatti, Manuela& Bertoni, Laura…[et al.]. 2013. Inhibition of Nuclear Nox4 Activity by Plumbagin : Effect on Proliferative Capacity in Human Amniotic Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guida, Marianna…[et al.]. Inhibition of Nuclear Nox4 Activity by Plumbagin : Effect on Proliferative Capacity in Human Amniotic Stem Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-490013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guida, Marianna& Maraldi, Tullia& Resca, Elisa& Beretti, Francesca& Zavatti, Manuela& Bertoni, Laura…[et al.]. Inhibition of Nuclear Nox4 Activity by Plumbagin : Effect on Proliferative Capacity in Human Amniotic Stem Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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