Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes

الملخص EN

Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity.

The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB).

Fifty-seven patients with type 2 diabetes underwent RYGB.

Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB.

Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications.

Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB.

BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P=0.024).

Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group).

Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline.

There was a difference in the change in the BMP-4 level according to remission status.

Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.