Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes
Joint Authors
Kim, Eung Kook
Hong, Oak-Kee
Yoo, Soon-Jib
Song, Ki-Ho
Kim, Wook
Baek, Ki-Hyun
Jang, Eun-Hee
Chun, Hyun-Ji
Kim, Mee Kyoung
Kwon, Hyuk-Sang
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity.
The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB).
Fifty-seven patients with type 2 diabetes underwent RYGB.
Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB.
Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications.
Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB.
BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline (P=0.024).
Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group).
Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline.
There was a difference in the change in the BMP-4 level according to remission status.
Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.
American Psychological Association (APA)
Kim, Mee Kyoung& Jang, Eun-Hee& Hong, Oak-Kee& Chun, Hyun-Ji& Yoo, Soon-Jib& Baek, Ki-Hyun…[et al.]. 2013. Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-490040
Modern Language Association (MLA)
Kim, Mee Kyoung…[et al.]. Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-490040
American Medical Association (AMA)
Kim, Mee Kyoung& Jang, Eun-Hee& Hong, Oak-Kee& Chun, Hyun-Ji& Yoo, Soon-Jib& Baek, Ki-Hyun…[et al.]. Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-490040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490040