![](/images/graphics-bg.png)
Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata
المؤلفون المشاركون
Lai, Chih-Ho
Lin, Chun-Jung
Tzeng, Yew-Min
Hsu, Ping-Ning
Rao, Yerra Koteswara
Feng, Chun-Lung
Hung, Chiu-Lien
Tzeng, David T. W.
Lane, Hsien-Yuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The bacterial pathogen Helicobacter pylori (Hp) is the leading risk factor for the development of gastric cancer.
Hp virulence factor, cytotoxin-associated gene A (CagA) interacted with cholesterol-enriched microdomains and leads to induction of inflammation in gastric epithelial cells (AGS).
In this study, we identified a triterpenoid methylantcinate B (MAB) from the medicinal mushroom Antrodia camphoratawhich inhibited the translocation and phosphorylation of CagA and caused a reduction in hummingbird phenotype in HP-infected AGS cells.
Additionally, MAB suppressed the Hp-induced inflammatory response by attenuation of NF-κB activation, translocation of p65 NF-κB, and phosphorylation of IκB-α, indicating that MAB modulates CagA-mediated signaling pathway.
Additionally, MAB also suppressed the IL-8 luciferase activity and its secretion in HP-infected AGS cells.
On the other hand, molecular structure simulations revealed that MAB interacts with CagA similarly to that of cholesterol.
Moreover, binding of cholesterol to the immobilized CagA was inhibited by increased levels of MAB.
Our results demonstrate that MAB is the first natural triterpenoid which competes with cholesterol bound to CagA leading to attenuation of Hp-induced pathogenesis of epithelial cells.
Thus, this study indicates that MAB may have a scope to develop as a therapeutic candidate against Hp CagA-induced inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chun-Jung& Rao, Yerra Koteswara& Hung, Chiu-Lien& Feng, Chun-Lung& Lane, Hsien-Yuan& Tzeng, David T. W.…[et al.]. 2013. Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chun-Jung…[et al.]. Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-490160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chun-Jung& Rao, Yerra Koteswara& Hung, Chiu-Lien& Feng, Chun-Lung& Lane, Hsien-Yuan& Tzeng, David T. W.…[et al.]. Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-490160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)