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Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies
المؤلفون المشاركون
Rosa, Jaime
Galassetti, Pietro
Tran, Brian
Oliver, Stacy
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Obesity and type 1 diabetes (T1DM) are the two most common conditions of altered metabolism in children and adolescents.
In both, similar long-term cardiovascular complications are known to occur, mediated in large part by underlying inflammatory and oxidative processes whose biochemical details remain relatively unclear.
Through a series of experiments in these patient populations, over the last decade our laboratory has clarified a number of key issues in this field.
Interestingly, while obese and type 1 diabetic children often differed in the specific type and magnitude of molecular alterations, in both groups a clear exaggeration of inflammatory and oxidative activation was detected when compared to healthy, age-matched controls.
Our main findings include definition of resting and exercise-induced cytokine patterns and leukocyte profiles, patterns of activation of immune cells in vitro, and correlation of the magnitude of observed alterations with severity of obesity and quality of glycemic control.
Further, we have identified a series of alterations in growth factor profiles during exercise that parallel inflammatory changes in obese children.
This paper offers a concise overview of the salient results from this decade-long research effort.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tran, Brian& Oliver, Stacy& Rosa, Jaime& Galassetti, Pietro. 2012. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tran, Brian…[et al.]. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-490270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tran, Brian& Oliver, Stacy& Rosa, Jaime& Galassetti, Pietro. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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