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Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies
Joint Authors
Rosa, Jaime
Galassetti, Pietro
Tran, Brian
Oliver, Stacy
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity and type 1 diabetes (T1DM) are the two most common conditions of altered metabolism in children and adolescents.
In both, similar long-term cardiovascular complications are known to occur, mediated in large part by underlying inflammatory and oxidative processes whose biochemical details remain relatively unclear.
Through a series of experiments in these patient populations, over the last decade our laboratory has clarified a number of key issues in this field.
Interestingly, while obese and type 1 diabetic children often differed in the specific type and magnitude of molecular alterations, in both groups a clear exaggeration of inflammatory and oxidative activation was detected when compared to healthy, age-matched controls.
Our main findings include definition of resting and exercise-induced cytokine patterns and leukocyte profiles, patterns of activation of immune cells in vitro, and correlation of the magnitude of observed alterations with severity of obesity and quality of glycemic control.
Further, we have identified a series of alterations in growth factor profiles during exercise that parallel inflammatory changes in obese children.
This paper offers a concise overview of the salient results from this decade-long research effort.
American Psychological Association (APA)
Tran, Brian& Oliver, Stacy& Rosa, Jaime& Galassetti, Pietro. 2012. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490270
Modern Language Association (MLA)
Tran, Brian…[et al.]. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-490270
American Medical Association (AMA)
Tran, Brian& Oliver, Stacy& Rosa, Jaime& Galassetti, Pietro. Aspects of Inflammation and Oxidative Stress in Pediatric Obesity and Type 1 Diabetes : An Overview of Ten Years of Studies. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-490270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490270