Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model
المؤلفون المشاركون
Lai, Ming-Tsung
Chung, Jing-Gung
Liu, Fon-Chang
Pan, Chun-Hsu
Wu, Chieh-Hsi
Chang, Shu-Jen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The aim of this study was to explore the antitumor effect of Gan-Lu-Yin (GLY), a traditional Chinese herbal formula, on leukemia.
Ethanolic extract of GLY was applied to evaluate its regulatory mechanisms in proliferation, migration, and differentiation of WEHI-3 leukemic cells as well as antitumor effect on BALB/c mice model.
The results showed that GLY markedly reduced cell proliferation and migration with induced differentiation of WEHI-3 cells.
The expression level of phosphorylated FAK, Akt, ERK1/2, and Rb was decreased p21 expression while level was increased in WEHI-3 treated with GLY.
The results of cell cycle analysis revealed that GLY treatment could markedly induce G1 phase arrest and decrease cell population in S phase.
Moreover, experimental results demonstrated that GLY decreased the protein expression and enzyme activity of MMP-2 and MMP-9.
GLY treatment also reduced WEHI-3 leukemic infiltration in liver and spleen and tumor growth in animal model.
Accordingly, GLY demonstrated an inhibitory effect on tumor growth with a regulatory mechanism partially through inhibiting FAK, Akt, and ERK expression in WEHI-3 cells.
GLY may provide a promising antileukemic approach in the clinical application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Fon-Chang& Pan, Chun-Hsu& Lai, Ming-Tsung& Chang, Shu-Jen& Chung, Jing-Gung& Wu, Chieh-Hsi. 2013. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490315
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Fon-Chang…[et al.]. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-490315
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Fon-Chang& Pan, Chun-Hsu& Lai, Ming-Tsung& Chang, Shu-Jen& Chung, Jing-Gung& Wu, Chieh-Hsi. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490315
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490315
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر