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Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model
Joint Authors
Lai, Ming-Tsung
Chung, Jing-Gung
Liu, Fon-Chang
Pan, Chun-Hsu
Wu, Chieh-Hsi
Chang, Shu-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aim of this study was to explore the antitumor effect of Gan-Lu-Yin (GLY), a traditional Chinese herbal formula, on leukemia.
Ethanolic extract of GLY was applied to evaluate its regulatory mechanisms in proliferation, migration, and differentiation of WEHI-3 leukemic cells as well as antitumor effect on BALB/c mice model.
The results showed that GLY markedly reduced cell proliferation and migration with induced differentiation of WEHI-3 cells.
The expression level of phosphorylated FAK, Akt, ERK1/2, and Rb was decreased p21 expression while level was increased in WEHI-3 treated with GLY.
The results of cell cycle analysis revealed that GLY treatment could markedly induce G1 phase arrest and decrease cell population in S phase.
Moreover, experimental results demonstrated that GLY decreased the protein expression and enzyme activity of MMP-2 and MMP-9.
GLY treatment also reduced WEHI-3 leukemic infiltration in liver and spleen and tumor growth in animal model.
Accordingly, GLY demonstrated an inhibitory effect on tumor growth with a regulatory mechanism partially through inhibiting FAK, Akt, and ERK expression in WEHI-3 cells.
GLY may provide a promising antileukemic approach in the clinical application.
American Psychological Association (APA)
Liu, Fon-Chang& Pan, Chun-Hsu& Lai, Ming-Tsung& Chang, Shu-Jen& Chung, Jing-Gung& Wu, Chieh-Hsi. 2013. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490315
Modern Language Association (MLA)
Liu, Fon-Chang…[et al.]. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-490315
American Medical Association (AMA)
Liu, Fon-Chang& Pan, Chun-Hsu& Lai, Ming-Tsung& Chang, Shu-Jen& Chung, Jing-Gung& Wu, Chieh-Hsi. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALBC Allograft Tumor Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490315