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Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study
المؤلفون المشاركون
Patel, Bharat G.
Bhatt, Kashyap K.
Patel, Mrunali R.
Patel, Rashmin B.
المصدر
Chromatography Research International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A new, simple, and rapid high-performance thin-layer chromatographic method was developed and validated for quantitative determination of Carbamazepine.
Carbamazepine was chromatographed on silica gel 60 F254 TLC plate using ethyl acetate-toluene-methanol (5.0 + 4.0 + 1.0 v/v/v) as mobile phase.
Carbamazepine was quantified by densitometric analysis at 285 nm.
The method was found to give compact spots for the drug (Rf=0.47 ± 0.01).
The linear regression analysis data for the calibration plots showed good linear relationship with r2=.9995 in the concentration range 100–600 ng/spot.
The method was validated for precision, recovery, repeatability, and robustness as per the International Conference on Harmonization guidelines.
The minimum detectable amount was found to be 16.7 ng/spot, whereas the limit of quantitation was found to be 50.44 ng/spot.
Statistical analysis of the data showed that the method is precise, accurate, reproducible, and selective for the analysis of Carbamazepine.
The method was successfully employed for the estimation of equilibrium solubility, quantification of Carbamazepine as a bulk drug, in commercially available preparation, and in-house developed mucoadhesive microemulsion formulations and solution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Rashmin B.& Patel, Mrunali R.& Bhatt, Kashyap K.& Patel, Bharat G.. 2010. Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study. Chromatography Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490349
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Rashmin B.…[et al.]. Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study. Chromatography Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-490349
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Rashmin B.& Patel, Mrunali R.& Bhatt, Kashyap K.& Patel, Bharat G.. Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study. Chromatography Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-490349
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490349
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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