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Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood
المؤلفون المشاركون
Rocha, Susana
Belo, Luís
Quintanilha, Alexandre
Rebelo, Irene
Rocha-Pereira, Petronila
Santos-Silva, Alice
Catarino, Cristina
Patrício, Belmiro
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity.
PE is associated with an inflammatory state and with oxidative stress, in maternal circulation.
Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies.
We measured acute-phase proteins (CRP and α1-antitrypsin), proinflammatory cytokines (IL-6 and TNF-α), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), and uric acid levels.
We studied 42 healthy pregnant women, 46 PE women, and their neonates.
The concentrations of IL-6, TNF-α, α1-antitrypsin, CRP, sVCAM, uric acid, and TBARS were significantly higher, and sL-selectin was significantly lower in PE pregnant women as compared with normotensive pregnant women.
In newborns uric acid, α1-antitrypsin, and CRP values were significantly higher in PE; leukocyte count, sL-selectin, lactoferrin, and the ratio elastase/α1-antitrypsin were significantly lower.
Our data suggest that PE pregnancy is associated with an enhanced maternal inflammatory condition, which is reflected in fetal circulation.
This enhanced inflammatory state seems to be related to endothelial dysfunction and increased cytokine synthesis, rather than with neutrophil activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Catarino, Cristina& Santos-Silva, Alice& Belo, Luís& Rocha-Pereira, Petronila& Rocha, Susana& Patrício, Belmiro…[et al.]. 2012. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Catarino, Cristina…[et al.]. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Catarino, Cristina& Santos-Silva, Alice& Belo, Luís& Rocha-Pereira, Petronila& Rocha, Susana& Patrício, Belmiro…[et al.]. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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