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Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood
Joint Authors
Rocha, Susana
Belo, Luís
Quintanilha, Alexandre
Rebelo, Irene
Rocha-Pereira, Petronila
Santos-Silva, Alice
Catarino, Cristina
Patrício, Belmiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity.
PE is associated with an inflammatory state and with oxidative stress, in maternal circulation.
Our aim was to evaluate and compare the levels of oxidative stress and inflammatory markers in maternal and umbilical cord blood (UCB), in normal and PE pregnancies.
We measured acute-phase proteins (CRP and α1-antitrypsin), proinflammatory cytokines (IL-6 and TNF-α), leukocyte activation (elastase, lactoferrin, sL-selectin, sVCAM, sPECAM), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), and uric acid levels.
We studied 42 healthy pregnant women, 46 PE women, and their neonates.
The concentrations of IL-6, TNF-α, α1-antitrypsin, CRP, sVCAM, uric acid, and TBARS were significantly higher, and sL-selectin was significantly lower in PE pregnant women as compared with normotensive pregnant women.
In newborns uric acid, α1-antitrypsin, and CRP values were significantly higher in PE; leukocyte count, sL-selectin, lactoferrin, and the ratio elastase/α1-antitrypsin were significantly lower.
Our data suggest that PE pregnancy is associated with an enhanced maternal inflammatory condition, which is reflected in fetal circulation.
This enhanced inflammatory state seems to be related to endothelial dysfunction and increased cytokine synthesis, rather than with neutrophil activation.
American Psychological Association (APA)
Catarino, Cristina& Santos-Silva, Alice& Belo, Luís& Rocha-Pereira, Petronila& Rocha, Susana& Patrício, Belmiro…[et al.]. 2012. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490351
Modern Language Association (MLA)
Catarino, Cristina…[et al.]. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490351
American Medical Association (AMA)
Catarino, Cristina& Santos-Silva, Alice& Belo, Luís& Rocha-Pereira, Petronila& Rocha, Susana& Patrício, Belmiro…[et al.]. Inflammatory Disturbances in Preeclampsia : Relationship between Maternal and Umbilical Cord Blood. Journal of Pregnancy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490351