Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model
المؤلفون المشاركون
Bonamin, Leoni Villano
de Santana, Fabiana Rodrigues
Osugui, Lika
Morante, Graziela
Mariano, Mario
Hurtado, Elizabeth Cristina Perez
Zalla Neto, Ruggero
Popi, Ana Flavia
Cardoso, Thayná Neves
Sato, Cesar
Coelho, Cideli de Paula
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The present study analyzed the immune modulation mechanisms of thymulin 5CH in a granuloma experimental model.
Male adult Balb/c mice were inoculated with BCG into the footpad to induce granuloma, which was quantitatively evaluated.
The phenotypic characterization of phagocyte, T- and B-lymphocyte populations in the peritoneum, and local lymph node was done by flow cytometry.
During all experimental periods, thymulin 5CH and vehicle (control) were given ad libitum to mice, diluted into the drinking water (1.6×10−17 M).
After 7 days from inoculation, thymulin-treated mice presented reduction in the number of epithelioid cytokeratine-positive cells (P=0.0001) in the lesion, in relation to young phagocytes.
After 21 days, the differentiation of B1 peritoneal stem cells into phagocytes reached the peak, being higher in thymulin-treated mice (P=0.0001).
Simultaneously, the score of infected phagocytes in the lesion decreased (P=0.001), and the number of B1-derived phagocytes, CD4+ and CD8+ T lymphocytes in the local lymph node increased in relation to control (P=0.0001).
No difference was seen on the CD25+ Treg cells.
The results show that thymulin 5CH treatment is able to improve the granuloma inflammatory process and the infection remission, by modulating local and systemic phagocyte differentiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bonamin, Leoni Villano& Sato, Cesar& Zalla Neto, Ruggero& Morante, Graziela& Cardoso, Thayná Neves& de Santana, Fabiana Rodrigues…[et al.]. 2013. Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-490506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bonamin, Leoni Villano…[et al.]. Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-490506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bonamin, Leoni Villano& Sato, Cesar& Zalla Neto, Ruggero& Morante, Graziela& Cardoso, Thayná Neves& de Santana, Fabiana Rodrigues…[et al.]. Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-490506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر