Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
المؤلفون المشاركون
Minami, Masahito
Yamaguchi, Kanji
Okanoue, Takeshi
Itoh, Yoshito
Yasui, Kohichiroh
Mitsuyoshi, Hironori
المصدر
International Journal of Hepatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated.
We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC.
Methods.
Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients.
The levels of serum soluble TNF-α receptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns.
Results.
Serum transaminase levels and hepatic scores of stage, grade, and steatosis were higher in patients with REC iron staining than in those without.
REC iron scores were independently associated with advanced stage.
Serum sTNFR2 levels were significantly higher in patients with REC iron than in those without.
REC iron scores were independently correlated with sTNFR2 levels.
Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin.
The efficacy of phlebotomy was greater in patients with REC iron than in those without REC iron.
Conclusions.
The present results show the importance of REC iron for the development of CHepC and the therapeutic effect of phlebotomy in CHepC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mitsuyoshi, Hironori& Yasui, Kohichiroh& Yamaguchi, Kanji& Minami, Masahito& Okanoue, Takeshi& Itoh, Yoshito. 2013. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-490550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mitsuyoshi, Hironori…[et al.]. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-490550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mitsuyoshi, Hironori& Yasui, Kohichiroh& Yamaguchi, Kanji& Minami, Masahito& Okanoue, Takeshi& Itoh, Yoshito. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-490550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر