Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
Joint Authors
Minami, Masahito
Yamaguchi, Kanji
Okanoue, Takeshi
Itoh, Yoshito
Yasui, Kohichiroh
Mitsuyoshi, Hironori
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated.
We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC.
Methods.
Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients.
The levels of serum soluble TNF-α receptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns.
Results.
Serum transaminase levels and hepatic scores of stage, grade, and steatosis were higher in patients with REC iron staining than in those without.
REC iron scores were independently associated with advanced stage.
Serum sTNFR2 levels were significantly higher in patients with REC iron than in those without.
REC iron scores were independently correlated with sTNFR2 levels.
Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin.
The efficacy of phlebotomy was greater in patients with REC iron than in those without REC iron.
Conclusions.
The present results show the importance of REC iron for the development of CHepC and the therapeutic effect of phlebotomy in CHepC.
American Psychological Association (APA)
Mitsuyoshi, Hironori& Yasui, Kohichiroh& Yamaguchi, Kanji& Minami, Masahito& Okanoue, Takeshi& Itoh, Yoshito. 2013. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-490550
Modern Language Association (MLA)
Mitsuyoshi, Hironori…[et al.]. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-490550
American Medical Association (AMA)
Mitsuyoshi, Hironori& Yasui, Kohichiroh& Yamaguchi, Kanji& Minami, Masahito& Okanoue, Takeshi& Itoh, Yoshito. Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-490550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490550