Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice

المؤلفون المشاركون

Barbier, Nathalie
Boudousquié, Caroline
Blanchard, Carine
Thierry, Anne-Christine
Pellaton, Céline
Mercenier, Annick
Nutten, Sophie
Spertini, François
Corthésy, Blaise

المصدر

International Journal of Inflammation

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-06-17

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

Preclinical and clinical evidences for a role of oral probiotics in the management of allergic diseases are emerging.

Aim.

We aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of Lactobacillus paracasei NCC2461 in a mouse model of allergic airway inflammation and the specificity of different probiotics by comparing L.

paracasei NCC2461 to Lactobacillus plantarum NCC1107.

Methods.

L.

paracasei NCC2461 or L.

plantarum NCC1107 strains were administered either intragastrically (NCC2461) or intranasally (NCC2461 or NCC1107) to OVA-sensitized mice challenged with OVA aerosols.

Inflammatory cell recruitment into BALF, eotaxin and IL-5 production in the lungs were measured.

Results.

Intranasal L.

paracasei NCC2461 efficiently protected sensitized mice upon exposure to OVA aerosols in a dose-dependent manner as compared to control mice.

Inflammatory cell number, eotaxin and IL-5 were significantly reduced in BALF.

Intranasal supplementation of L.

paracasei NCC2461 was more potent than intragastric application in limiting the allergic response and possibly linked to an increase in T regulatory cells in the lungs.

Finally, intranasal L.

plantarum NCC1107 reduced total and eosinophilic lung inflammation, but increased neutrophilia and macrophages infiltration.

Conclusion.

A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly contribute to modulate airway inflammation in a probiotic strain-specific manner.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Pellaton, Céline& Nutten, Sophie& Thierry, Anne-Christine& Boudousquié, Caroline& Barbier, Nathalie& Blanchard, Carine…[et al.]. 2012. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490573

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Pellaton, Céline…[et al.]. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490573

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Pellaton, Céline& Nutten, Sophie& Thierry, Anne-Christine& Boudousquié, Caroline& Barbier, Nathalie& Blanchard, Carine…[et al.]. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490573

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-490573